Doctors are hailing a new drug that can prevent premature ejaculation extending the length of sexual intercourse. Dapoxetine, marketed as Priligy (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting theserotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.  As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant. It is extremely expensive in the Uk, about £70 for three tablets, but no doubt supplies coming from such places as India, will force the price downwards. Dapoxetine is chemically similar to a family of antidepressants called SSRIs (selective serotonin reuptake inhibitors).  These types of antidepressants are known to have an impact on ejaculation.


Trials of dapoxetine have shown a trebling of the duration of intercourse. The beneficial effect occurred after the first dose and increased over the study period. Sex educationalist Seb Cox commenting on the research said “Premature ejaculation is a huge problem. All men suffer in varying degrees, and as men we are often very uncomfortable talking about sex, it’s very much a hidden problem. I have been writing for years about the possibility that some anti depressant drugs seemed to have the effect of delaying ejaculation, just as this drug is doing. Now that dapoxetine is available I think it will have an even bigger effect than Viagra on how men have sex, and of course, just like Viagra, few will admit to using it, and the manufacturers would never suggest using it for recreational effect.

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